Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally
Identifieur interne : 000B95 ( Main/Exploration ); précédent : 000B94; suivant : 000B96Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally
Auteurs : Alexandru Hanganu [Canada] ; Christophe Bedetti [Canada] ; Clotilde Degroot [Canada] ; Beatriz Mejia-Constain [Canada] ; Anne-Louise Lafontaine [Canada] ; Valerie Soland [Canada] ; Sylvain Chouinard [Canada] ; Marie-Andrée Bruneau [Canada] ; Samira Mellah [Canada] ; Sylvie Belleville [Canada] ; Oury Monchi [Canada]Source :
- Brain [ 0006-8950 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally</title><author><name sortKey="Hanganu, Alexandru" sort="Hanganu, Alexandru" uniqKey="Hanganu A" first="Alexandru" last="Hanganu">Alexandru Hanganu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de 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longitudinally</title><author><name sortKey="Hanganu, Alexandru" sort="Hanganu, Alexandru" uniqKey="Hanganu A" first="Alexandru" last="Hanganu">Alexandru Hanganu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Medicine du Sommeil, Hôpital du Sacré-Cœur de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Degroot, Clotilde" sort="Degroot, Clotilde" uniqKey="Degroot C" first="Clotilde" last="Degroot">Clotilde Degroot</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Radiology, Faculty of Medicine, University of Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejia-Constain">Beatriz Mejia-Constain</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Movement Disorders Unit, McGill University Health Centre</s1><s2>Montréal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, QC</wicri:noRegion></affiliation></author><author><name sortKey="Soland, Valerie" sort="Soland, Valerie" uniqKey="Soland V" first="Valerie" last="Soland">Valerie Soland</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Bruneau, Marie Andree" sort="Bruneau, Marie Andree" uniqKey="Bruneau M" first="Marie-Andrée" last="Bruneau">Marie-Andrée Bruneau</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Mellah, Samira" sort="Mellah, Samira" uniqKey="Mellah S" first="Samira" last="Mellah">Samira Mellah</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Belleville, Sylvie" sort="Belleville, Sylvie" uniqKey="Belleville S" first="Sylvie" last="Belleville">Sylvie Belleville</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Psychology, Université du Québec à Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Radiology, Faculty of Medicine, University of Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Human</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>mild cognitive impairment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Déficit cognitif léger</term><term>Trouble cognitif</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Homme</term><term>Imagerie RMN</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Hanganu, Alexandru" sort="Hanganu, Alexandru" uniqKey="Hanganu A" first="Alexandru" last="Hanganu">Alexandru Hanganu</name></noRegion><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Belleville, Sylvie" sort="Belleville, Sylvie" uniqKey="Belleville S" first="Sylvie" last="Belleville">Sylvie Belleville</name><name sortKey="Belleville, Sylvie" sort="Belleville, Sylvie" uniqKey="Belleville S" first="Sylvie" last="Belleville">Sylvie Belleville</name><name sortKey="Bruneau, Marie Andree" sort="Bruneau, Marie Andree" uniqKey="Bruneau M" first="Marie-Andrée" last="Bruneau">Marie-Andrée Bruneau</name><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name><name sortKey="Degroot, Clotilde" sort="Degroot, Clotilde" uniqKey="Degroot C" first="Clotilde" last="Degroot">Clotilde Degroot</name><name sortKey="Degroot, Clotilde" sort="Degroot, Clotilde" uniqKey="Degroot C" first="Clotilde" last="Degroot">Clotilde Degroot</name><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejia-Constain">Beatriz Mejia-Constain</name><name sortKey="Mellah, Samira" sort="Mellah, Samira" uniqKey="Mellah S" first="Samira" last="Mellah">Samira Mellah</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Soland, Valerie" sort="Soland, Valerie" uniqKey="Soland V" first="Valerie" last="Soland">Valerie Soland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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